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Infection and Immunity, June 2001, p. 4125-4128, Vol. 69, No. 6
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.6.4125-4128.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Local and Systemic Immune Responses to Rectal Administration of Recombinant Cholera Toxin B Subunit in Humans

Marianne Jertborn,1,2,* Inger Nordström,1 Anders Kilander,3 Cecil Czerkinsky,1,dagger and Jan Holmgren1

Department of Medical Microbiology and Immunology,1 Department of Infectious Diseases,2 and Institute of Internal Medicine, Department of Gastroenterology,3 Sahlgrenska University Hospital, Göteborg, Sweden

Received 20 June 2000/Returned for modification 22 August 2000/Accepted 22 February 2001

The induction of immune responses to rectally administered recombinant cholera toxin B subunit (CTB) in humans was studied. Three immunizations induced high levels of CTB-specific antibody-secreting cells, particular of the immunoglobulin A isotype, in both rectum and peripheral blood. Antitoxin antibody responses in rectal secretions and serum were also found.

* Corresponding author. Mailing address: Department of Medical Microbiology and Immunology, Göteborg University, Guldhedsgatan 10, 413 46 Göteborg, Sweden. Phone: 46-31-3424614. Fax: 46-31-826976. E-mail: marianne.jertborn{at}microbio.gu.se.

dagger Present address: INSERM Unit 364, Faculté de Médecine-Pasteur, Nice, France.

Infection and Immunity, June 2001, p. 4125-4128, Vol. 69, No. 6
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.6.4125-4128.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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