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Infection and Immunity, June 2001, p. 4164-4167, Vol. 69, No. 6
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.6.4164-4167.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

gp96-Peptide Vaccination of Mice against Intracellular Bacteria

Ulrich Zügel,1,dagger Anne-Marit Sponaas,2 Jutta Neckermann,1,Dagger Bernd Schoel,1,§ and Stefan H. E. Kaufmann1,2,*

Department of Immunology, University of Ulm, 89070 Ulm,1 and Max Planck Institute for Infection Biology, 10117 Berlin,2 Germany

Received 12 January 2001/Returned for modification 19 February 2001/Accepted 5 March 2001

This work demonstrates that gp96 preparations isolated from cells infected with intracellular bacteria induce cytotoxic T-lymphocyte responses and confer protection. Our findings extend previous reports on the immunogenicity of gp96-associated peptides to antigens derived from intracellular bacteria. Immunization with gp96 may therefore represent a promising vaccination strategy against bacterial pathogens.

* Corresponding author. Mailing address: Max-Planck-Institute for Infection Biology, Schumannstrasse 21-22, 10117 Berlin, Germany. Phone: (49)30-28460500. Fax: (49)30-28460503. E-mail: kaufmann{at}mpiib-berlin.mpg.de.

dagger Present address: Department of Experimental Dermatology, Schering AG, Berlin, Germany.

Dagger Present address: Department of Internal Medicine, University of Ulm, Ulm, Germany.

§ Present address: Genetic ID, Fairfield, Iowa.

Infection and Immunity, June 2001, p. 4164-4167, Vol. 69, No. 6
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.6.4164-4167.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

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