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Infection and Immunity, June 2001, p. 4174-4176, Vol. 69, No. 6
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.6.4174-4176.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Priming by DNA Immunization Augments Protective Efficacy of Mycobacterium bovis Bacille Calmette-Guerin against Tuberculosis

Carl G. Feng,1,2 Umaimainthan Palendira,1 Caroline Demangel,1,3 Joanne M. Spratt,1 Adam S. Malin,4 and Warwick J. Britton1,5,*

Centenary Institute of Cancer Medicine and Cell Biology, Newtown, New South Wales 2042,1 and Department of Medicine, University of Sydney, New South Wales 2006,5 Australia; Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-04252; Laboratoire d'Ingenierie des Anticorps, Institut Pasteur, 75724 Paris Cedex 15, France3; and Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, United Kingdom4

Received 28 December 2000/Returned for modification 5 February 2001/Accepted 7 March 2001

Sequential immunization with mycobacterial antigen Ag85B-expressing DNA and Mycobacterium bovis bacille Calmette-Guerin (BCG) was more effective than BCG immunization in protecting against Mycobacterium tuberculosis infection. Depletion of the CD8+ T cells in the immunized mice impaired protection in their spleens, indicating that this improved efficacy was partially mediated by CD8+ T cells.

* Corresponding author. Mailing address: Centenary Institute of Cancer Medicine and Cell Biology, Locked Bag No. 6, Newtown, NSW 2042, Australia. Phone: 61-2-9515 5210. Fax: 61-2-9351 3968. E-mail: wbritton{at}medicine.usyd.edu.au.

Infection and Immunity, June 2001, p. 4174-4176, Vol. 69, No. 6
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.6.4174-4176.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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