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Infection and Immunity, July 2001, p. 4667-4672, Vol. 69, No. 7
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.7.4667-4672.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Expression of Genes Encoding Th1 Cell-Activating Cytokines and Lymphoid Homing Chemokines by Chlamydia-Pulsed Dendritic Cells Correlates with Protective Immunizing Efficacy

Jennifer H. Shaw,1 Vernon R. Grund,2 Luke Durling,1 and Harlan D. Caldwell1,*

Laboratory of Intercellular Parasites, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratory, Hamilton, Montana 59840,1 and Department of Pharmaceutical Sciences, University of Montana, Missoula, Montana 598012

Received 26 February 2001/Returned for modification 9 April 2001/Accepted 16 April 2001

We studied the expression of cytokines, chemokines, and chemokine receptors by the RNase protection assay in chlamydia-pulsed dendritic cells to better understand their potent anti-chlamydial immunizing properties. We found that chlamydia-pulsed dendritic cells express a complex profile of inflammatory and immunomodulatory molecules. These include CCR-7, interleukin-12, and interferon-induced protein 10, molecules that might influence the homing of pulsed dendritic cells to the site of chlamydial infection and the induction of a local protective CD4+ Th1 cellular immunity.

* Corresponding author. Mailing address: Laboratory of Intercellular Parasites, National Institute of Allergy and Infectious Diseases, NIH Rocky Mountain Laboratory, 903 South 4th St., Hamilton, MT 59840. Phone: (406) 363-9333. Fax: (406) 363-9355. E-mail: hcaldwell{at}niaid.nih.gov.

Infection and Immunity, July 2001, p. 4667-4672, Vol. 69, No. 7
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.7.4667-4672.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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