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Infection and Immunity, August 2001, p. 5182-5185, Vol. 69, No. 8
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.8.5182-5185.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Concurrent Upregulation of Urokinase Plasminogen Activator Receptor and CD11b during Tuberculosis and Experimental Endotoxemia

Nicole P. Juffermans,1,2 Pascale E. P. Dekkers,1 Annelies Verbon,1,2 Peter Speelman,2 Sander J. H. van Deventer,1 and Tom van der Poll1,2,*

Laboratory of Experimental Internal Medicine1 and Department of Internal Medicine,2 Division of Infectious Diseases, Tropical Medicine and AIDS, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

Received 29 January 2001/Returned for modification 26 March 2001/Accepted 11 May 2001

Patients with tuberculosis had higher expression of monocyte urokinase receptor (uPAR) and CD11b than controls. In vitro, lipoarabinomannan and lipopolysaccharide (LPS) from Escherichia coli shared the ability to enhance uPAR and CD11b expression on monocytes and granulocytes. In healthy volunteers, LPS induced increases in monocyte and granulocyte uPAR and CD11b.

* Corresponding author. Mailing address: Poll, Laboratory of Experimental Medicine, Room G2-132, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. Phone: 31-20-5669111. Fax: 31-20-6977192. E-mail: t.vanderpoll{at}amc.uva.nl.

Infection and Immunity, August 2001, p. 5182-5185, Vol. 69, No. 8
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.8.5182-5185.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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