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Infection and Immunity, August 2001, p. 5186-5188, Vol. 69, No. 8
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.8.5186-5188.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Effect of Low-Dose Antigen Exposure on Development of Immunity to Helicobacter pylori Infection in Mice

Fiona J. Radcliffdagger and Richard L. Ferrero*

Unité de Pathogénie Bactérienne des Muqueuses, Institut Pasteur, Paris 75724, France

Received 26 February 2001/Returned for modification 18 April 2001/Accepted 14 May 2001

The effect of low-dose antigen exposure on the development of immunity to Helicobacter pylori infection was studied in outbred mice. Animals that were primed with a subinfectious number of H. pylori bacteria exhibited significantly lower bacterial loads after challenge with an infectious dose of pathogen (versus controls, P < 0.05).

* Corresponding author. Mailing address: Unité de Pathogénie Bactérienne des Muqueuses, Institut Pasteur, 28 Rue du Dr Roux, Paris 75724, France. Phone: 33 1 40613324. Fax: 33 1 40613640. E-mail: rferrero{at}pasteur.fr.

dagger Present address: Genesis Research and Development, Parnell, Auckland, New Zealand.

Infection and Immunity, August 2001, p. 5186-5188, Vol. 69, No. 8
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.8.5186-5188.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Raghavan, S., Hjulstrom, M., Holmgren, J., Svennerholm, A.-M. (2002). Protection against Experimental Helicobacter pylori Infection after Immunization with Inactivated H. pylori Whole-Cell Vaccines. Infect. Immun. 70: 6383-6388 [Abstract] [Full Text]  


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