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Infection and Immunity, August 2001, p. 5212-5215, Vol. 69, No. 8
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.8.5212-5215.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Mannan-Binding Lectin Enhances Susceptibility to Visceral Leishmaniasis

Isabel K. F. de Miranda Santos,1,2 Carlos H. N. Costa,1,3 Henrique Krieger,4 Mary F. Feitosa,5 David Zurakowski,6 Babak Fardin,7 Regis B. B. Gomes,3 Debra L. Weiner,8 Donald A. Harn,1 R. Alan B. Ezekowitz,7 and Judith E. Epstein9,*

Department of Immunology and Infectious Diseases, Harvard School of Public Health,1 and Department of Biostatistics,6 Division of Emergency Medicine,8 and Division of Infectious Diseases,9 Children's Hospital, Boston, Massachusetts 02115; Centro Nacional de Pesquisa de Recursos Genéticos e Biotecnologia, Empresa Brasileira de Pesquisa Agropecuária, Brasília, DF 70 770-900, Brazil2; Departamento de Medicina Comunitária, Centro de Ciências da Saúde, Universidade Federal do Piauí, Teresina, PI Brazil 64 0003; Departmento de Parasitologia, Institututo de Ciências Biomédicas, Universidade de São Paulo, São Paulo, SP, Brazil 05 508-9004; Departamento de Genética, Instituto Oswaldo Cruz, FIOCruz, Rio de Janeiro, RJ Brazil 21 045-9005; and Laboratory of Developmental Immunology, Massachusetts General Hospital, Boston, Massachusetts 021147

Received 2 November 2000/Returned for modification 2 February 2001/Accepted 11 May 2001

Levels of the serum opsonin mannan-binding lectin (MBL) were directly correlated with the probability of developing visceral leishmaniasis. Monocytes infected with MBL-opsonized Leishmania chagasi promastigotes secreted higher levels of tumor necrosis factor alpha and interleukin-6 than cells infected with nonopsonized parasites. Our findings indicate that MBL can modulate the clinical outcome of infection with L. chagasi and the function of infected macrophages.

* Corresponding author. Present address: Malaria Department, Naval Medical Research Center, 503 Robert Grant Ave., Silver Spring, MD 20910. Phone: (301) 319-7582. Fax: (301) 319-7545. E-mail: epsteinj{at}nmrc.navy.mil.

Infection and Immunity, August 2001, p. 5212-5215, Vol. 69, No. 8
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.8.5212-5215.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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