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Infection and Immunity, September 2001, p. 5908-5910, Vol. 69, No. 9
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.9.5908-5910.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

PcrV Immunization Enhances Survival of Burned Pseudomonas aeruginosa-Infected Mice

Ian Alan Holder,1,* Alice N. Neely,1 and Dara W. Frank2

Shriners Hospital for Children, Cincinnati, Ohio,1 and Medical College of Wisconsin, Milwaukee, Wisconsin2

Received 2 March 2001/Returned for modification 18 April 2001/Accepted 15 June 2001

Burned Pseudomonas aeruginosa-infected mice immunized against PcrV, a type III virulence system translocating protein, showed significantly enhanced survival compared to controls. Survival was non-O serotype specific and correlated with a reduced systemic microbial load. Infection with a high-level toxin A-producing strain required supplemental antitoxin treatment to enhance survival.

* Corresponding author. Mailing address: Department of Microbiology, Shriners Hospital for Children, 3229 Burnet Ave., Cincinnati, OH 45229. Phone: (513) 872-6350. Fax: (513) 872-6999. E-mail: iaholder{at}juno.com.

Infection and Immunity, September 2001, p. 5908-5910, Vol. 69, No. 9
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.9.5908-5910.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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