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Infection and Immunity, January 2002, p. 400-402, Vol. 70, No. 1
0019-9567/01/$04.00+0     DOI: 10.1128/IAI.70.1.400-402.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Production of Prostaglandins and Leukotrienes by Pathogenic Fungi

Mairi C. Noverr,1,2 Galen B. Toews,2 and Gary B. Huffnagle1,2*

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine,1 Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109-06422

Received 29 June 2001/ Returned for modification 9 August 2001/ Accepted 27 September 2001

These studies demonstrate that pathogenic fungi (dermatophytic, subcutaneous, and systemic) have the ability to produce eicosanoids both from simple metabolites and from arachidonic acid. Host-derived eicosanoids have been previously demonstrated to enhance fungal colonization and atopic disease development. Thus, fungus-derived eicosanoids represent a potential class of novel virulence factors.

* Corresponding author. Mailing address: Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109-0642. Phone: (734) 936-9369. Fax: (734) 764-4556. E-mail: ghuff{at}umich.edu.

Editor: T. R. Kozel

Infection and Immunity, January 2002, p. 400-402, Vol. 70, No. 1
0019-9567/01/$04.00+0     DOI: 10.1128/IAI.70.1.400-402.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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