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Infection and Immunity, October 2002, p. 5751-5758, Vol. 70, No. 10
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.10.5751-5758.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Independent Translocation of Two Micronemal Proteins in Developing Plasmodium falciparum Merozoites

Julie Healer,1 Simon Crawford,2 Stuart Ralph,2 Geoff McFadden,2 and Alan F. Cowman1*

The Walter and Eliza Hall Institute of Medical Research,1 School of Botany, University of Melbourne, Melbourne, Australia2

Received 6 February 2002/ Returned for modification 10 April 2002/ Accepted 18 June 2002

Apical membrane antigen 1 of Plasmodium falciparum (PfAMA1) contains an N-terminal propeptide that is removed prior to the translocation of the mature protein onto the merozoite surface. We localized unprocessed PfAMA1 to the microneme organelles of the intraerythrocytic schizont. The results have suggested that the processed form of PfAMA1 translocates from the microneme compartment independently of another microneme protein, EBA175, which is also involved in the invasion of human erythrocytes.

* Corresponding author. Mailing address: The Walter and Eliza Hall Institute of Medical Research, P.O. Royal Melbourne Hospital, Melbourne 3050, Australia. Phone: 613 9345 2555. Fax: 613 9347 0852. E-mail: cowman{at}wehi.edu.au.

Editor: R. N. Moore

Infection and Immunity, October 2002, p. 5751-5758, Vol. 70, No. 10
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.10.5751-5758.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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