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Infection and Immunity, October 2002, p. 5873-5876, Vol. 70, No. 10
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.10.5873-5876.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

A Monoclonal Antibody to the Amebic Lipophosphoglycan-Proteophosphoglycan Antigens Can Prevent Disease in Human Intestinal Xenografts Infected with Entamoeba histolytica

Zhi Zhang,1 Michael Duchêne,2 and Samuel L. Stanley, Jr.1,3*

Departments of Medicine,1 Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri 63110,3 Department of Pathophysiology, A-1090 Vienna, Austria2

Received 20 May 2002/ Returned for modification 14 June 2002/ Accepted 28 June 2002

Entamoeba histolytica trophozoites are covered by lipophosphoglycan-peptidoglycan molecules which may be key virulence factors. We found that pretreatment of severe combined immunodeficient mice bearing human intestinal xenografts with a monoclonal antibody to the amebic lipophosphoglycan-peptidoglycan molecules can prevent or significantly reduce the human intestinal inflammation and tissue damage that are normally seen with E. histolytica colonic infection.

* Corresponding author. Mailing address: Department of Medicine, Washington University School of Medicine, Campus Box 8051, 660 S. Euclid Ave., St. Louis, MO 63110. Phone: (314) 362-1070. Fax: (314) 362-3525. E-mail: sstanley{at}im.wustl.edu.

Editor: W. A. Petri, Jr.

Infection and Immunity, October 2002, p. 5873-5876, Vol. 70, No. 10
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.10.5873-5876.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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