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Infection and Immunity, December 2002, p. 7050-7053, Vol. 70, No. 12
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.12.7050-7053.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Lactoferrin Protects Rabbits from Shigella flexneri-Induced Inflammatory Enteritis

Henry F. Gomez, Theresa J. Ochoa, Irene Herrera-Insua, Lily G. Carlin, and Thomas G. Cleary*

Division of Infectious Diseases, Department of Pediatrics, University of Texas—Houston Medical School, Houston, Texas 77030

Received 26 April 2002/ Returned for modification 2 July 2002/ Accepted 3 September 2002

Shigella species cause bacillary dysentery in humans by invasion, intracellular multiplication, spread to adjacent cells, and induction of brisk inflammatory responses in the intestinal epithelium. In vitro data suggest that lactoferrin, a glycoprotein present in human mucosal secretions, has a role in protection from bacterial enteric infections. We sought to determine the activity of lactoferrin in vivo, using the concentration present in human colostrum, to investigate its effect on the development of clinical and pathological evidence of inflammation in a rabbit model of enteritis. Lactoferrin protected rabbits infected with Shigella flexneri from developing inflammatory intestinal disease. Typical histological changes in ill animals included villous blunting with sloughing of epithelial cells, submucosal edema, infiltration of leukocytes, venous congestion, and hemorrhage. Lactoferrin at a concentration normally found in human colostrum blocks development of S. flexneri-induced inflammatory enteritis.

* Corresponding author. Mailing address: Pediatric Infectious Diseases, 6431 Fannin St. JFB 1.739, Houston, TX 77030. Phone: (713) 500-5714. Fax: (713) 500-5688. E-mail: thomas.g.cleary{at}uth.tmc.edu.

Editor: J. D. Clements

Infection and Immunity, December 2002, p. 7050-7053, Vol. 70, No. 12
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.12.7050-7053.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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