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Infection and Immunity, December 2002, p. 7149-7152, Vol. 70, No. 12
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.12.7149-7152.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Nasal Immunization with Homogenate and Peptide Antigens Induces Protective Immunity against Trichinella spiralis

Carolann McGuire,1,{dagger} Weng C. Chan,2 and Derek Wakelin1*

School of Life and Environmental Sciences,1 School of Pharmaceutical Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom2

Received 11 April 2002/ Returned for modification 14 June 2002/ Accepted 22 August 2002

Mice were successfully immunized against the intestinal nematode Trichinella spiralis by intranasal administration of a 30-mer peptide antigen with cholera toxin B. Immunized mice developed antigen-specific serum immunoglobulin G1, intestinal immunoglobulin A, and a type 2-biased cytokine response. Intranasal immunization therefore generates the Th2-mediated responses required for immunity against intestinal parasites.

* Corresponding author. Mailing address: School of Life and Environmental Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom. Phone: (44) 115-9513232. Fax: (44) 115-9513252. E-mail: D.Wakelin{at}nottingham.ac.uk.

Editor: J. M. Mansfield

{dagger} Present address: Allergy and Inflammation Sciences, School of Medicine, University of Southampton, Southampton SO16 7PX, United Kingdom.

Infection and Immunity, December 2002, p. 7149-7152, Vol. 70, No. 12
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.12.7149-7152.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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