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Infection and Immunity, February 2002, p. 512-516, Vol. 70, No. 2
0019-9567/01/$04.00+0     DOI: 10.1128/IAI.70.2.512-516.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Association of a Determinant on Mouse Chromosome 18 with Experimental Severe Plasmodium berghei Malaria

Eiji Nagayasu,1 Koichi Nagakura,2 Mayumi Akaki,1 Gen Tamiya,3 Satoshi Makino,3 Yamaji Nakano,1 Minoru Kimura,3 and Masamichi Aikawa1*

Institute of Science and Technology,1 Division of Molecular Life Science, School of Medicine,3 Division of Infectious Diseases, Tokai University, Isehara 259-1193, Japan2

Received 29 May 2001/ Returned for modification 28 August 2001/ Accepted 12 November 2001

Experimental severe malaria (ESM; also known as experimental cerebral malaria) is an acute lethal syndrome caused by infection with Plasmodium berghei ANKA and associated with coma and other neurological manifestations in mice. Various inbred strains of mice exhibit differences in susceptibility to the development of ESM. For example, C57BL/6 mice are highly susceptible and DBA/2 mice are relatively resistant. We report here the results of a genomewide scan for host genomic regions that control resistance to ESM in DBA/2 mice using an F2 intercross population of susceptible and resistant strains. A region of mid-chromosome 18 was found to be a major determinant of resistance to ESM.

* Corresponding author. Mailing address: Institute of Science and Technology, Tokai University, Isehara 259-1193, Japan. Phone: 81-463-93-1121 (2559). Fax: 81-463-93-7087. E-mail: aikawa{at}is.icc.u-tokai.ac.jp.

Editor: J. M. Mansfield

Infection and Immunity, February 2002, p. 512-516, Vol. 70, No. 2
0019-9567/01/$04.00+0     DOI: 10.1128/IAI.70.2.512-516.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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