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Infection and Immunity, February 2002, p. 981-984, Vol. 70, No. 2
0019-9567/01/$04.00+0     DOI: 10.1128/IAI.70.2.981-984.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

HLA-B*35-Restricted CD8+-T-Cell Epitope in Mycobacterium tuberculosis Rv2903c

Michèl R. Klein,1* Abdulrahman S. Hammond,1 Steve M. Smith,2,{dagger} Assan Jaye,1 Pauline T. Lukey,3 and Keith P. W. J. McAdam1

TB Research Programme, MRC Laboratories, Fajara, The Gambia,1 Immunology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London,2 Respiratory Systems, GlaxoSmithKline R&D, Medicines Research Centre, Stevenage, Hertfordshire United Kingdom3

Received 14 May 2001/ Returned for modification 10 July 2001/ Accepted 22 October 2001

Few human CD8+ T-cell epitopes in mycobacterial antigens have been described to date. Here we have identified a novel HLA-B*35-restricted CD8+ T-cell epitope in Mycobacterium tuberculosis Rv2903c based on a reverse immunogenetics approach. Peptide-specific CD8 T cells were able to kill M. tuberculosis-infected macrophages and produce gamma interferon and tumor necrosis factor alpha.

* Corresponding author. Present address: Department of Microbiology and Immunology, School of Medicine, Stanford University, 279 Campus Dr., Beckman Center B239 (Schoolnik Lab), Stanford, CA 94305-5323. Phone: (650) 723-7026. Fax: (650) 723-1399. E-mail: petiet{at}stanford.edu.

Editor: S. H. E. Kaufmann

{dagger} Present address: Department of Pathology and Microbiology, University of Bristol, Bristol, United Kingdom.

Infection and Immunity, February 2002, p. 981-984, Vol. 70, No. 2
0019-9567/01/$04.00+0     DOI: 10.1128/IAI.70.2.981-984.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Li, Z., Diaz-Montero, C. M., Valbuena, G., Yu, X.-J., Olano, J. P., Feng, H.-M., Walker, D. H. (2003). Identification of CD8 T-Lymphocyte Epitopes in OmpB of Rickettsia conorii. Infect. Immun. 71: 3920-3926 [Abstract] [Full Text]  


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