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Infection and Immunity, April 2002, p. 2206-2209, Vol. 70, No. 4
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.4.2206-2209.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Cortactin Is Necessary for F-Actin Accumulation in Pedestal Structures Induced by Enteropathogenic Escherichia coli Infection

Vlademir V. Cantarelli,1,2 Akira Takahashi,1,3 Itaru Yanagihara,1 Yukihiro Akeda,1 Kinichi Imura,1 Toshio Kodama,1 Gengo Kono,1 Yoshihisa Sato,1 Tetsuya Iida,1 and Takeshi Honda1*

Department of Bacterial Infections, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871 ,1 Department of Nutrition, School of Medicine, Tokushima University, Tokushima 770-8503, Japan ,3 Laboratorio Weinmann LTDA, Porto Alegre, RS, Brazil2

Received 9 August 2001/ Returned for modification 19 November 2001/ Accepted 29 November 2001

Cortactin and the translocated intimin receptor, Tir, interacted with each other in pedestal formation in HeLa cells infected with enteropathogenic Escherichia coli (EPEC). Cortactin is shown to be necessary for organizing actin pedestals in response to EPEC, based on the expression of green fluorescent protein-fused cortactin derivatives in HeLa cells.

* Corresponding author. Mailing address: Department of Bacterial Infections, Research Institute for Microbial Diseases, Osaka University, Yamadaoka 3-1, Suita, Osaka 565-0871, Japan. Phone: 81-6-6879-8278. Fax: 81-6-6879-8277. E-mail: honda{at}biken.osaka-u.ac.jp.

Infection and Immunity, April 2002, p. 2206-2209, Vol. 70, No. 4
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.4.2206-2209.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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