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Infection and Immunity, April 2002, p. 2220-2225, Vol. 70, No. 4
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.4.2220-2225.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Extended Repertoire of Genes Encoding Variable Surface Lipoproteins in Mycoplasma bovis Strains

Sarit Nussbaum,1 Inessa Lysnyansky,1 Konrad Sachse,2 Sharon Levisohn,3 and David Yogev1*

Department of Membrane and Ultrastructure Research, The Hebrew University—Hadassah Medical School, Jerusalem 91120,1 Mycoplasma Unit, Kimron Veterinary Institute, Bet Dagan 50250, Israel,3 Federal Institute for Health Protection of Consumersand Veterinary Medicine, Division 4, Jena, Germany2

Received 10 August 2001/ Returned for modification 4 December 2001/ Accepted 8 January 2002

A genomic cluster of vsp genes was previously shown to mediate high-frequency phenotypic switching of surface lipoprotein antigens in the bovine pathogen Mycoplasma bovis. This study revealed that field strains of M. bovis possess modified versions of the vsp gene complex in which extensive sequence variations occur primarily in the reiterated coding sequences of the vsp structural genes. These findings demonstrate that there is a vastly expanded potential for antigenic variation within populations of this organism.

* Corresponding author. Mailing address: Department of Membrane and Ultrastructure Research, The Hebrew University—Hadassah Medical School, Jerusalem 91120, Israel. Phone: 972-2-6758176. Fax: 972-2-6784010. E-mail: yogev{at}cc.huji.ac.il.

Editor: V. J. DiRita

Infection and Immunity, April 2002, p. 2220-2225, Vol. 70, No. 4
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.4.2220-2225.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Flitman-Tene, R., Mudahi-Orenstein, S., Levisohn, S., Yogev, D. (2003). Variable Lipoprotein Genes of Mycoplasma agalactiae Are Activated In Vivo by Promoter Addition via Site-Specific DNA Inversions. Infect. Immun. 71: 3821-3830 [Abstract] [Full Text]  


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