This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Svensson, L. A.
Right arrow Articles by Lagergård, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Svensson, L. A.
Right arrow Articles by Lagergård, T.

 Previous Article  |  Next Article 

Infection and Immunity, May 2002, p. 2665-2669, Vol. 70, No. 5
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.5.2665-2669.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

The Cytolethal Distending Toxin of Haemophilus ducreyi Inhibits Endothelial Cell Proliferation

Liselott A. Svensson, Petra Henning, and Teresa Lagergård*

Department of Medical Microbiology and Immunology, Göteborg University, S-4136 Göteborg, Sweden

Received 31 August 2001/ Returned for modification 4 November 2001/ Accepted 29 January 2002

Haemophilus ducreyi, the etiologic agent of the sexually transmitted disease chancroid, produces a cytolethal distending toxin (HdCDT) that inhibits mammalian cell proliferation. We investigated the effects of HdCDT on normal human endothelial cells and on tubule formation in an in vitro model of angiogenesis. Endothelial cells were arrested in the G2 phase of the cell cycle, and tubule formation was inhibited in a dose-dependent manner. The antiproliferative activities of HdCDT on endothelial cells might contribute to the characteristic slow healing and persistence of chancroid ulcers.

* Corresponding author. Mailing address: Department of Medical Microbiology and Immunology, Göteborg University, S-4136 Göteborg, Sweden. Phone: 46-31-3424758. Fax: 46-31-820160. E-mail: teresa.lagergard{at}microbio.gu.se.

Editor: A. D. O'Brien

Infection and Immunity, May 2002, p. 2665-2669, Vol. 70, No. 5
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.5.2665-2669.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Heywood, W., Henderson, B., Nair, S. P (2005). Cytolethal distending toxin: creating a gap in the cell cycle. J Med Microbiol 54: 207-216 [Abstract] [Full Text]  
  • Bielaszewska, M., Sinha, B., Kuczius, T., Karch, H. (2005). Cytolethal Distending Toxin from Shiga Toxin-Producing Escherichia coli O157 Causes Irreversible G2/M Arrest, Inhibition of Proliferation, and Death of Human Endothelial Cells. Infect. Immun. 73: 552-562 [Abstract] [Full Text]  
  • Ohara, M., Oswald, E., Sugai, M. (2004). Cytolethal Distending Toxin: A Bacterial Bullet Targeted to Nucleus. J Biochem 136: 409-413 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»