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Infection and Immunity, May 2002, p. 2690-2693, Vol. 70, No. 5
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.5.2690-2693.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Gamma Interferon Fails To Induce Expression of Indoleamine 2,3-Dioxygenase and Does Not Control the Growth of Chlamydophila abortus in BeWo Trophoblast Cells

Gary Entrican,1* Sean Wattegedera,1 Michelle Chui,1 Lyn Oemar,1 Mara Rocchi,1,,2 and Colin McInnes1

Moredun Research Institute, Pentlands Science Park, Bush Loan, Edinburgh EH26 0PZ,1 Department of Veterinary Clinical Studies, University of Edinburgh, Easter Bush, Edinburgh EH25 9RG, Scotland, United Kingdom2

Received 21 August 2001/ Returned for modification 29 October 2001/ Accepted 24 January 2002

The BeWo trophoblast cell line does not constitutively express the tryptophan degrading enzyme indolamine 2,3-dioxygenase (IDO), nor can IDO expression be induced by gamma interferon. This correlates with the inability of BeWo cells to control the growth of Chlamydophila abortus, in contrast to effects observed in HeLa cells treated with gamma interferon.

* Corresponding author. Mailing address: Moredun Research Institute, Pentlands Science Park, Bush Loan, Edinburgh EH26 0PZ, Scotland, United Kingdom. Phone: 0131-445-5111. Fax: 0131-445-6235. E-mail: gary.entrican{at}mri.sari.ac.uk.

Editor: S. H. E. Kaufmann

Infection and Immunity, May 2002, p. 2690-2693, Vol. 70, No. 5
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.5.2690-2693.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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