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Infection and Immunity, May 2002, p. 2700-2703, Vol. 70, No. 5
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.5.2700-2703.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Identification and Functional Analysis of an Immunoreactive DsbA-Like Thio-Disulfide Oxidoreductase of Ehrlichia spp.

Jere W. McBride,* Lucy M. Ndip, Vsevolod L. Popov, and David H. Walker

Department of Pathology and WHO Collaborating Center for Tropical Diseases, University of Texas Medical Branch, Galveston, Texas 77555-0609

Received 26 October 2001/ Returned for modification 18 December 2001/ Accepted 1 February 2002

Novel homologous DsbA-like disulfide bond formation (Dsb) proteins of Ehrlichia chaffeensis and Ehrlichia canis were identified which restored DsbA activity in complemented Escherichia coli dsbA mutants. Recombinant Ehrlichia Dsb (eDsb) proteins were recognized by sera from E. canis-infected dogs but not from E. chaffeensis-infected patients. The eDsb proteins were observed primarily in the periplasm of E. chaffeensis and E. canis.

* Corresponding author. Mailing address: Department of Pathology, 301 University Blvd., University of Texas Medical Branch, Galveston, TX 77555-0609. Phone: (409) 772-4813. Fax: (409) 747-2415. E-mail: jemcbrid{at}utmb.edu.

Editor: J. T. Barbieri

Infection and Immunity, May 2002, p. 2700-2703, Vol. 70, No. 5
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.5.2700-2703.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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