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Infection and Immunity, June 2002, p. 3068-3072, Vol. 70, No. 6
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.6.3068-3072.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

ß-Defensin 1 Contributes to Pulmonary Innate Immunity in Mice

Christian Moser,1 Daniel J. Weiner,1,2 Elena Lysenko,3 Robert Bals,1,{dagger} Jeffrey N. Weiser,3 and James M. Wilson1*

Institute for Human Gene Therapy, Departments of Medicine and Molecular and Cellular Engineering, University of Pennsylvania, and The Wistar Institute,1 Division of Pulmonary Medicine, Children's Hospital of Philadelphia,2 Departments of Microbiology and Pediatrics, University of Pennsylvania, Philadelphia, Pennsylvania 191043

Received 7 January 2002/ Returned for modification 22 February 2002/ Accepted 14 March 2002

Innate immunity serves as a first line defense in vertebrate organisms by providing an initial barrier to microorganisms and triggering antigen-specific responses. Antimicrobial peptides are thought to be effectors of innate immunity through their antibiotic activity and direct killing of microorganisms. Evidence to support this hypothesis in vertebrates is indirect, based on expression profiles and in vitro assays using purified peptides. Here we investigated the function of antimicrobial peptides in vivo using mice deficient in an antimicrobial peptide, mouse ß-defensin-1 (mBD-1). We find that loss of mBD-1 results in delayed clearance of Haemophilus influenzae from lung. These data demonstrate directly that antimicrobial peptides of vertebrates provide an initial block to bacteria at epithelial surfaces.

* Corresponding author. Mailing address: 204 Wistar Institute, 3601 Spruce St., Philadelphia, PA 19104-4268. Phone: (215) 898-3000. Fax: (215) 898-6588. E-mail: wilsonjm{at}mail.med.upenn.edu.

Editor: J. D. Clements

{dagger} Present address: Klinikum Grosshadern, University of Munich, Munich, Germany.

Infection and Immunity, June 2002, p. 3068-3072, Vol. 70, No. 6
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.6.3068-3072.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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