This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sakash, J. B.
Right arrow Articles by Libby, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sakash, J. B.
Right arrow Articles by Libby, P.

 Previous Article  |  Next Article 

Infection and Immunity, July 2002, p. 3959-3961, Vol. 70, No. 7
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.7.3959-3961.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Cytokines Induce Indoleamine 2,3-Dioxygenase Expression in Human Atheroma-Associated Cells: Implications for Persistent Chlamydophila pneumoniae Infection

Jessica B. Sakash,1,2 Gerald I. Byrne,3 Andrew Lichtman,1 and Peter Libby2*

Vascular Research Division Department of Pathology, and,1 Leducq Center for Cardiovascular Research, Brigham and Women's Hospital, Boston, Massachusetts 02115,2 Department of Medical Microbiology and Immunology, University of Wisconsin, Madison, Wisconsin 537063

Received 26 December 2001/ Returned for modification 26 February 2002/ Accepted 2 April 2002

This study shows that vascular smooth muscle cells express significantly higher levels of gamma interferon-inducible indoleamine 2,3-dioxygenase (IDO) activity than endothelium or mononuclear cells. Since IDO activity is linked to persistent Chlamydophila pneumoniae infection, our results suggest that smooth muscle cells may be an important reservoir of that organism in atherosclerosis.

* Corresponding author. Mailing address: Leducq Center for Cardiovascular Research, Brigham and Women's Hospital, 221 Longwood Ave., Boston, MA 02115. Phone: (617) 732-6628. Fax: (617) 732-6961. E-mail: plibby{at}rics.bwh.harvard.edu.

Editor: J. T. Barbieri

Infection and Immunity, July 2002, p. 3959-3961, Vol. 70, No. 7
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.7.3959-3961.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Jalili, R. B., Forouzandeh, F., Moeenrezakhanlou, A., Rayat, G. R., Rajotte, R. V., Uludag, H., Ghahary, A. (2009). Mouse Pancreatic Islets Are Resistant to Indoleamine 2,3 Dioxygenase-Induced General Control Nonderepressible-2 Kinase Stress Pathway and Maintain Normal Viability and Function. Am. J. Pathol. 174: 196-205 [Abstract] [Full Text]  
  • Tsao, C-W., Lin, Y-S., Cheng, J-T., Lin, C-F., Wu, H-T., Wu, S-R., Tsai, W-H. (2008). Interferon-{alpha}-induced serotonin uptake in Jurkat T cells via mitogen-activated protein kinase and transcriptional regulation of the serotonin transporter. J Psychopharmacol 22: 753-760 [Abstract]  
  • Cuffy, M. C., Silverio, A. M., Qin, L., Wang, Y., Eid, R., Brandacher, G., Lakkis, F. G., Fuchs, D., Pober, J. S., Tellides, G. (2007). Induction of Indoleamine 2,3-Dioxygenase in Vascular Smooth Muscle Cells by Interferon-{gamma} Contributes to Medial Immunoprivilege. J. Immunol. 179: 5246-5254 [Abstract] [Full Text]  
  • Hogan, R. J., Mathews, S. A., Mukhopadhyay, S., Summersgill, J. T., Timms, P. (2004). Chlamydial Persistence: beyond the Biphasic Paradigm. Infect. Immun. 72: 1843-1855 [Full Text]  
  • Kalayoglu, M. V., Libby, P., Byrne, G. I. (2002). Chlamydia pneumoniae as an Emerging Risk Factor in Cardiovascular Disease. JAMA 288: 2724-2731 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»