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Infection and Immunity, July 2002, p. 3965-3968, Vol. 70, No. 7
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.7.3965-3968.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Mycobacterium tuberculosis CDC1551 Is Resistant to Reactive Nitrogen and Oxygen Intermediates In Vitro

Marcia A. Firmani and Lee W. Riley*

School of Public Health, Division of Infectious Disease, University of California at Berkeley, Berkeley, California 94720

Received 26 November 2001/ Returned for modification 24 January 2002/ Accepted 26 March 2002

Resistance to reactive oxygen intermediates and reactive nitrogen intermediates in vitro of a clinical isolate of Mycobacterium tuberculosis (CDC1551) that caused a large outbreak of tuberculosis was compared to that of M. tuberculosis strains CB3.3, H37Rv, H37Ra, Erdman, RJ2E, C.C. 13, and C.C. 22 as well as M. bovis strains Ravenel and BCG. CDC1551 and CB3.3 were significantly more resistant to both hydrogen peroxide (H2O2) and acidified sodium nitrite than were the other strains tested. This biological phenotype may serve as an in vitro marker for clinical strains of M. tuberculosis likely to cause a large outbreak of tuberculosis.

* Corresponding author. Mailing address: School of Public Health, Division of Infectious Diseases, 140 Warren Hall, University of California, Berkeley, Berkeley, CA 94720. Phone: (510) 642-9200. Fax: (510) 642-6350. E-mail: lwriley{at}uclink4.berkeley.edu.

Editor: S. H. E. Kaufmann

Infection and Immunity, July 2002, p. 3965-3968, Vol. 70, No. 7
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.7.3965-3968.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Cantrell, S. A., Pascopella, L., Flood, J., Crane, C. M., Kendall, L. V., Riley, L. W. (2008). Community-wide transmission of a strain of Mycobacterium tuberculosis that causes reduced lung pathology in mice. J Med Microbiol 57: 21-27 [Abstract] [Full Text]  
  • Brugmann, W. B., Firmani, M. A. (2005). Low Concentrations of Nitric Oxide Exert a Hormetic Effect on Mycobacterium tuberculosis In Vitro. J. Clin. Microbiol. 43: 4844-4846 [Abstract] [Full Text]  


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