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Infection and Immunity, August 2002, p. 4726-4728, Vol. 70, No. 8
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.8.4726-4728.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Alternative Splicing of LYT1 Transcripts in Trypanosoma cruzi

Rebeca Manning-Cela,1,2 Antonio González,3 and John Swindle2*

Departamento de Biomedicina Molecular, Centro de Investigación y de Estudios Avanzados del IPN, México, D.F., México,1 Infection Disease Research Institute, Seattle, Washington,2 Instituto de Parasitología y Biomedicina, CSIC, Granada, Spain3

Received 11 February 2002/ Returned for modification 11 April 2002/ Accepted 1 May 2002

As a result of alternative trans splicing, three distinct LYT1 mRNAs are produced in Trypanosoma cruzi, two encoding the full-length LYT1 protein and the third encoding a truncated LYT1 protein lacking a possible signal sequence. Analysis of the three mRNAs in different developmental forms of the parasite revealed that the alternative processing events were regulated differently during the parasite life cycle.

* Corresponding author. Mailing address: Infection Disease Research Institute, 1124 Columbia St., Suite 600, Seattle, WA 98104. Phone: (206) 381-0883. Fax: (206) 381-3678. E-mail: jswindle{at}idri.org.

Editor: W. A. Petri, Jr.

Infection and Immunity, August 2002, p. 4726-4728, Vol. 70, No. 8
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.8.4726-4728.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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