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Infection and Immunity, September 2002, p. 5265-5268, Vol. 70, No. 9
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.9.5265-5268.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Simultaneous Expression of Different Variant-Specific Surface Proteins in Single Giardia lamblia Trophozoites during Encystation

Pedro G. Carranza, Gisela Feltes, Andrea Ropolo, Silvia M. C. Quintana, María C. Touz, and Hugo D. Luján*

Cátedra de Bioquímica y Biología Molecular, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, CP 5000 Córdoba, Argentina

Received 18 March 2002/ Returned for modification 11 May 2002/ Accepted 25 May 2002

A novel variant-specific surface protein (VSP) from Giardia was identified using the monoclonal antibody 9B10, raised against purified cyst walls. VSP9B10B is preferentially induced during encystation and expressed simultaneously with other VSPs on the surface of encysting trophozoites. These results support the hypothesis that encystation and antigenic variation are processes that are mechanistically related.

* Corresponding author. Mailing address: Cátedra de Bioquímica y Biología Molecular, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Pabellón Argentina 2do piso, Ciudad Universitaria, CP 5000 Córdoba, Argentina. Phone and fax: (54) (351) 433-3024. E-mail: hlujan{at}biomed.uncor.edu.

Editor: W. A. Petri, Jr.

Infection and Immunity, September 2002, p. 5265-5268, Vol. 70, No. 9
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.9.5265-5268.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.





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