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Infection and Immunity, September 2002, p. 5319-5321, Vol. 70, No. 9
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.9.5319-5321.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Identification of Genes Affecting Salmonella enterica Serovar Enteritidis Infection of Chicken Macrophages

Yixian Zhao, Ruud Jansen, Wim Gaastra, Ger Arkesteijn, Bernard A. M. van der Zeijst, and Jos P. M. van Putten*

Department of Infectious Diseases and Immunology, Utrecht University, 3584 CL Utrecht, The Netherlands

Received 8 November 2001/ Returned for modification 5 February 2002/ Accepted 11 June 2002

Screening of 7,680 Salmonella enterica serovar Enteritidis mutants for attenuation in a chicken macrophage infection model yielded a series of mutants including several with defects in previously unrecognized Salmonella virulence genes. One of the newly identified genes was the pbpA2 gene, belonging to the penicillin binding protein gene family.

* Corresponding author. Mailing address: Department of Infectious Diseases and Immunology, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The Netherlands. Phone: 31 30 253 4344. Fax: 31 30 254 0784. E-mail: j.vanputten{at}vet.uu.nl.

Editor: V. J. DiRita

Infection and Immunity, September 2002, p. 5319-5321, Vol. 70, No. 9
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.9.5319-5321.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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