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Infection and Immunity, September 2002, p. 5322-5327, Vol. 70, No. 9
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.9.5322-5327.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Neutrophil-Mediated Mycobacteriocidal Immunity in the Lung during Mycobacterium bovis BCG Infection in C57BL/6 Mice

S. A. Fulton,* S. M. Reba, T. D. Martin,,{dagger} and W. H. Boom

Division of Infectious Diseases, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio 44106-4984

Received 3 December 2001/ Returned for modification 12 February 2002/ Accepted 22 May 2002

Although neutrophils have been identified as sources of inflammatory cytokines and chemokines, little is known about their immunologic function during mycobacterial infection in the lungs. In this study, we examined the growth of Mycobacterium bovis BCG in the lungs under experimental conditions that altered neutrophil recruitment to the lungs. Depletion and recruitment of neutrophils was associated with respective increases and decreases in M. bovis BCG growth. Thus, neutrophils may enhance mycobacteriocidal immunity in the lungs.

* Corresponding author. Mailing address: Division of Infectious Diseases, Case Western Reserve University, Biomedical Research Building, 1010B, 10900 Euclid Ave., Cleveland, OH 44106-4984. Phone: (216) 368-8900. Fax: (216) 368-2034. E-mail: sxf24{at}po.cwru.edu.

Editor: S. H. E. Kaufmann

{dagger} Present address: National Cancer Institute, Frederick, MD 21702.

Infection and Immunity, September 2002, p. 5322-5327, Vol. 70, No. 9
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.9.5322-5327.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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