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Infection and Immunity, October 2003, p. 6054-6057, Vol. 71, No. 10
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.10.6054-6057.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Antibody Responses Elicited against the Treponema pallidum Repeat Proteins Differ during Infection with Different Isolates of Treponema pallidum subsp. pallidum

Brandon T. Leader,1 Karin Hevner,2 Barbara J. Molini,2 Lynn K. Barrett,2 Wesley C. Van Voorhis,1,2 and Sheila A. Lukehart1,2*

Departments of Pathobiology,1 Medicine, University of Washington, Seattle, Washington 98195-71852

Received 9 May 2003/ Returned for modification 12 June 2003/ Accepted 26 July 2003

Variation in the expression of the different Tpr proteins in the syphilis spirochete, Treponema pallidum subsp. pallidum, may have important implications in its ability to evade host immune detection and cause persistent infection. In the present study we examined the pattern of antibody responsiveness to different Tpr members during infection with three isolates of T. pallidum. There was variability in the specificities and temporal patterns of reactivity of the antibodies elicited against the individual Tpr proteins, suggesting that isolates may express different repertoires of Tpr proteins during infection.

* Corresponding author. Mailing address: Department of Medicine, Box 359779, Harborview Medical Center, 325 Ninth Ave., Seattle WA 98104. Phone: (206) 341-5362. Fax: (206) 341-5363. E-mail: lukehart{at}u.washington.edu.

Editor: W. A. Petri, Jr.

Infection and Immunity, October 2003, p. 6054-6057, Vol. 71, No. 10
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.10.6054-6057.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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