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Infection and Immunity, October 2003, p. 6058-6062, Vol. 71, No. 10
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.10.6058-6062.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Differential Contribution of Toll-Like Receptors 4 and 2 to the Cytokine Response to Salmonella enterica Serovar Typhimurium and Staphylococcus aureus in Mice

Annalisa Lembo,1 Christoph Kalis,1 Carsten J. Kirschning,2 Vincenzo Mitolo,3 Emilio Jirillo,4 Hermann Wagner,2 Chris Galanos,1 and Marina A. Freudenberg1*

Max-Planck-Institut für Immunbiologie, 79108 Freiburg,1 Institute for Medical Microbiology, Immunology, and Hygiene, Technische Universität München, Munich, Germany,2 Institute of Anatomy, Faculty of Medicine,3 Department of Clinical Medicine, Immunology and Infectious Diseases, Faculty of Medicine, University of Bari, Policlinico, 70124 Bari, Italy4

Received 6 March 2003/ Returned for modification 5 April 2003/ Accepted 14 July 2003

The contribution of murine Toll-like receptors 2 and 4 (TLR2 and -4, respectively) to cytokine induction by heat-killed bacteria was analyzed in vitro and in vivo. Gram-negative bacteria induced cytokines primarily via TLR4; the contribution of TLR2 was only minor. Neither TLR4 nor, surprisingly, TLR2 was required in the MyD88-dependent response to Staphylococcus aureus.

* Corresponding author. Mailing address: Max-Planck-Institut für Immunbiologie, Stübeweg 51, 79108 Freiburg, Germany. Phone: 49 761 5108 404. Fax: 49 761 5108 403. E-mail: freudenberg{at}immunbio.mpg.de.

Editor: F. C. Fang

Infection and Immunity, October 2003, p. 6058-6062, Vol. 71, No. 10
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.10.6058-6062.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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