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Infection and Immunity, November 2003, p. 6610-6614, Vol. 71, No. 11
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.11.6610-6614.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Commensal Bacteria Increase Invasion of Intestinal Epithelium by Salmonella enterica Serovar Typhi

The Channing Laboratory, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts 02115

Received 19 June 2003/ Returned for modification 18 July 2003/ Accepted 12 August 2003

The intestinal microflora consists of a heterogeneous population of microorganisms and has many effects on the health status of its human host. Here, it is shown that the products of certain strains of bacteria normally present in the intestinal microflora are able to trigger redistribution of the cystic fibrosis transmembrane conductance regulator (CFTR) protein in epithelial cells. CFTR is used by Salmonella enterica serovar Typhi as a receptor on epithelial cells which mediate the translocation of this microorganism to the gastric submucosa. Serovar Typhi-epithelial cell adhesion and CFTR-dependent invasion by serovar Typhi of epithelial cells were increased following commensal-mediated CFTR redistribution. These data suggest that commensal microorganisms present in the intestinal lumen can affect the efficiency of serovar Typhi invasion of the intestinal submucosa. This could be a key factor influencing host susceptibility to typhoid fever.

Editor: J. N. Weiser

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