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Infection and Immunity, November 2003, p. 6653-6657, Vol. 71, No. 11
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.11.6653-6657.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Toll-Like Receptor Expression in C3H/HeN and C3H/HeJ Mice during Salmonella enterica Serovar Typhimurium Infection

Sabine Tötemeyer,1* Neil Foster,2 Pete Kaiser,2 Duncan J. Maskell,1 and Clare E. Bryant1

Centre for Veterinary Science, Department of Clinical Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES,1 Institute for Animal Health, Compton, Newbury, Berkshire RG20 7NN, United Kingdom2

Received 24 March 2003/ Returned for modification 27 May 2003/ Accepted 27 July 2003

Here, we have investigated the mRNA expression of Toll-like receptor 2 (TLR-2), TLR-4, and MD-2 in spleens and livers of C3H/HeN mice (carrying wild-type TLR-4) and C3H/HeJ mice (carrying mutated TLR-4) in response to Salmonella infection. During Salmonella infections, TLR-4 is activated, leading to increased TLR-2 and decreased TLR-4 expression.

* Corresponding author. Mailing address: Centre for Veterinary Science, Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, United Kingdom. Phone: 44-1223-339547. Fax: 44-1223-337610. E-mail address: st262{at}cam.ac.uk.

Editor: A. D. O'Brien

Infection and Immunity, November 2003, p. 6653-6657, Vol. 71, No. 11
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.11.6653-6657.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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