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Infection and Immunity, November 2003, p. 6668-6671, Vol. 71, No. 11
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.11.6668-6671.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Increased Density of Human Immunodeficiency Virus Type 1 Coreceptors CCR5 and CXCR4 on the Surfaces of CD4+ T Cells and Monocytes of Patients with Schistosoma mansoni Infection

W. Evan Secor,1* Amil Shah,2 Pauline M. N. Mwinzi,2 Bryson A. Ndenga,2 Caroline O. Watta,2 and Diana M. S. Karanja2

Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia 30341,1 Centre for Vector Biology and Control Research, Kenya Medical Research Institute, Kisumu, Kenya2

Received 15 May 2003/ Returned for modification 18 June 2003/ Accepted 8 August 2003

Distribution of chemokine receptors CCR5 and CXCR4, which are also coreceptors for human immunodeficiency virus type 1 invasion of cells, was measured on the surfaces of CD4+ T cells and monocytes in peripheral blood samples from a group of Kenyan car washers. Patients with active schistosomiasis displayed higher cell surface densities of these receptors than did cured schistosomiasis patients.

* Corresponding author. Mailing address: Immunology Branch, Division of Parasitic Diseases, Centers for Disease Control and Prevention, 4770 Buford Highway, NE, MS-F13, Atlanta, GA 30341-3724. Phone: (770) 488-4115. Fax: (770) 488-4108. E-mail: was4{at}cdc.gov.

Editor: J. M. Mansfield

Infection and Immunity, November 2003, p. 6668-6671, Vol. 71, No. 11
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.11.6668-6671.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Ayash-Rashkovsky, M., Chenine, A.-L., Steele, L. N., Lee, S. J., Song, R., Ong, H., Rasmussen, R. A., Hofmann-Lehmann, R., Else, J. G., Augostini, P., McClure, H. M., Secor, W. E., Ruprecht, R. M. (2007). Coinfection with Schistosoma mansoni Reactivates Viremia in Rhesus Macaques with Chronic Simian-Human Immunodeficiency Virus Clade C Infection. Infect. Immun. 75: 1751-1756 [Abstract] [Full Text]  


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