This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Baldwin, T. M.
Right arrow Articles by Handman, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Baldwin, T. M.
Right arrow Articles by Handman, E.

 Previous Article  |  Next Article 

Infection and Immunity, December 2003, p. 6830-6834, Vol. 71, No. 12
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.12.6830-6834.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

The Site of Leishmania major Infection Determines Disease Severity and Immune Responses

Tracey M. Baldwin, Colleen Elso, Joan Curtis, Lynn Buckingham, and Emanuela Handman*

The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia

Received 9 June 2003/ Returned for modification 2 August 2003/ Accepted 30 August 2003

Inbred strains of mice infected with Leishmania major have been classified as genetically resistant or susceptible on the basis of their ability to cure their lesions, the parasite burden in the draining lymph nodes, and their type of T helper cell immune responses to the parasite. Using the intradermal infection at the base of the tail and the ear pinna, we compared for the first time the above-mentioned parameters in six strains of mice infected with metacyclic promastigotes, and we show that the severity of disease depends greatly on the site of infection. Although the well-documented pattern of disease susceptibility of BALB/c and C57BL/6 mice described for the footpad and base-of-the-tail models of leishmaniasis were confirmed, C3H/HeN and DBA/2 mice, which are intermediate and susceptible, respectively, in the tail and other models, were resistant to ear infection. Moreover, in the CBA/H, C3H/HeN, C57BL/6J, and DBA/2 mouse strains, there was little correlation between the pattern of cytokines produced and the disease phenotype observed at the ear and tail sites. We conclude that the definition of susceptibility and the immune mechanisms leading to susceptibility or resistance to infection may differ substantially depending on the route of infection.

* Corresponding author. Mailing address: The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia. Phone: 61-3-9345-2476. Fax: 61-3-9347-0852. E-mail: handman{at}wehi.edu.au.

Editor: W. A. Petri, Jr.

Infection and Immunity, December 2003, p. 6830-6834, Vol. 71, No. 12
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.12.6830-6834.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Duthie, M. S., Reece, S. T., Lahiri, R., Goto, W., Raman, V. S., Kaplan, J., Ireton, G. C., Bertholet, S., Gillis, T. P., Krahenbuhl, J. L., Reed, S. G. (2007). Antigen-Specific Cellular and Humoral Responses Are Induced by Intradermal Mycobacterium leprae Infection of the Mouse Ear. Infect. Immun. 75: 5290-5297 [Abstract] [Full Text]  
  • Rosas, L. E., Keiser, T., Barbi, J., Satoskar, A. A., Septer, A., Kaczmarek, J., Lezama-Davila, C. M., Satoskar, A. R. (2005). Genetic background influences immune responses and disease outcome of cutaneous L. mexicana infection in mice. Int Immunol 17: 1347-1357 [Abstract] [Full Text]  
  • de Moura, T. R., Novais, F. O., Oliveira, F., Clarencio, J., Noronha, A., Barral, A., Brodskyn, C., de Oliveira, C. I. (2005). Toward a Novel Experimental Model of Infection To Study American Cutaneous Leishmaniasis Caused by Leishmania braziliensis. Infect. Immun. 73: 5827-5834 [Abstract] [Full Text]  
  • Tabbara, K. S., Peters, N. C., Afrin, F., Mendez, S., Bertholet, S., Belkaid, Y., Sacks, D. L. (2005). Conditions Influencing the Efficacy of Vaccination with Live Organisms against Leishmania major Infection. Infect. Immun. 73: 4714-4722 [Abstract] [Full Text]  
  • Baldwin, T., Henri, S., Curtis, J., O'Keeffe, M., Vremec, D., Shortman, K., Handman, E. (2004). Dendritic Cell Populations in Leishmania major-Infected Skin and Draining Lymph Nodes. Infect. Immun. 72: 1991-2001 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»