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Infection and Immunity, December 2003, p. 7183-7187, Vol. 71, No. 12
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.12.7183-7187.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Inducible Nitric Oxide Synthase Regulates Production of Isoprostanes In Vivo during Chlamydial Genital Infection in Mice

K. H. Ramsey,1* I. M. Sigar,1 S. V. Rana,1 J. Gupta,1 S. M. Holland,2 G. I. Byrne,3 and J. D. Morrow4

Department of Microbiology, Chicago College of Osteopathic Medicine, Midwestern University, Downers Grove, Illinois 60515,1 Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892,2 Department of Molecular Sciences, University of Tennessee Health Sciences Center, Memphis, Tennessee 38163,3 Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 372324

Received 11 July 2003/ Returned for modification 4 August 2003/ Accepted 3 September 2003

Urinary nitrite and F2-isoprostanes, an index of oxidant stress, were elevated during chlamydial genital infection of mice. Enhancement of urinary nitrite and F2-isoprostanes was observed in phagocyte oxidase-deficient mice. Inhibition of inducible nitric oxide synthase reduced isoprostane excretion. We conclude that nitrogen radicals induce F2-isoprostane production and excretion during murine chlamydial genital infection.

* Corresponding author. Mailing address: Department of Microbiology, Chicago College of Osteopathic Medicine, Midwestern University, 555 31st Street, Downers Grove, IL 60515. Phone: (630) 515-6165. Fax: (630) 515-7245. E-mail: kramse{at}midwestern.edu.

Editor: F. C. Fang

Infection and Immunity, December 2003, p. 7183-7187, Vol. 71, No. 12
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.12.7183-7187.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Refaat, B., Al-Azemi, M., Geary, I., Eley, A., Ledger, W. (2009). Role of Activins and Inducible Nitric Oxide in the Pathogenesis of Ectopic Pregnancy in Patients with or without Chlamydia trachomatis Infection. CVI 16: 1493-1503 [Abstract] [Full Text]  
  • Rudolph, V., Freeman, B. A. (2009). Cardiovascular Consequences When Nitric Oxide and Lipid Signaling Converge. Circ. Res. 105: 511-522 [Abstract] [Full Text]  
  • Janssen, L. J. (2008). Isoprostanes and Lung Vascular Pathology. Am. J. Respir. Cell Mol. Bio. 39: 383-389 [Abstract] [Full Text]  


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