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Infection and Immunity, December 2003, p. 7211-7214, Vol. 71, No. 12
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.12.7211-7214.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Immunogenicity of Borrelia burgdorferi Arthritis-Related Protein

Sunlian Feng, Emir Hodzic, Kimberly Freet, and Stephen W. Barthold*

Center for Comparative Medicine, Schools of Medicine and Veterinary Medicine, University of California at Davis, Davis, California 95616

Received 30 May 2003/ Returned for modification 16 July 2003/ Accepted 2 September 2003

Immunization against arthritis-related protein (Arp) elicits antibody in mice that resolves arthritis but is not protective against challenge with Borrelia burgdorferi. In mice immunized against Arp, an unrelated 37-kDa protein (P37-42), outer surface protein A (OspA), or glutathione S-transferase (GT) and then challenged by syringe or tick, only OspA conferred protection. Passive transfer of Arp antiserum into infected SCID mice induced arthritis resolution, but antisera to P37-42, OspA, GT, or six overlapping Arp peptide fragments did not. Results suggest that the arthritis-resolving immunogenicity is specific to Arp, but the relevant epitopes may be conformational.

* Corresponding author. Mailing address: Center for Comparative Medicine, University of California at Davis, One Shields Ave., Davis, CA 95616. Phone: (530) 752-1245. Fax: (530) 752-7914. E-mail: swbarthold{at}ucdavis.edu.

Editor: F. C. Fang

Infection and Immunity, December 2003, p. 7211-7214, Vol. 71, No. 12
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.12.7211-7214.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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