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Infection and Immunity, December 2003, p. 7223-7227, Vol. 71, No. 12
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.12.7223-7227.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Mycobacterium avium subsp. paratuberculosis Infection Causes Suppression of RANTES, Monocyte Chemoattractant Protein 1, and Tumor Necrosis Factor Alpha Expression in Peripheral Blood of Experimentally Infected Cattle

Joram J. Buza,1 Yasuyuki Mori,2 Abusaleh M. Bari,1 Hirokazu Hikono Aodon-geril,1 Sachiyo Hirayama,1 Yujing Shu,1 and Eiichi Momotani1*

Paratuberculosis and Inflammatory Bowel Disease Research Team,1 Immune System Section, National Institute of Animal Health, 3-1-5 Kan-nondai, Tsukuba 305-0856, Japan2

Received 24 February 2003/ Returned for modification 8 April 2003/ Accepted 2 July 2003

Blood from cattle with subclinical Mycobacterium avium subsp. paratuberculosis infection was stimulated with M. avium subsp. paratuberculosis antigens, and expression of interleukin-1ß (IL-1ß), tumor necrosis factor alpha (TNF-{alpha}), RANTES, monocyte chemoattractant protein 1 (MCP-1), and IL-8 was measured. Expression of TNF-{alpha}, RANTES, and MCP-1 was lower in infected than in uninfected cattle. The reduced response may weaken protective immunity and perpetuate infection.

* Corresponding author. Mailing address: Paratuberculosis and Inflammatory Bowel Disease Research Team, NIAH, 3-1-5 Kan-nondai, Tsukuba 305-0856, Japan. Phone: 81-29-838-7781. Fax: 81-29-838-7781. E-mail: momotani{at}affrc.go.jp.

Editor: S. H. E. Kaufmann

Infection and Immunity, December 2003, p. 7223-7227, Vol. 71, No. 12
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.12.7223-7227.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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