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Infection and Immunity, February 2003, p. 1008-1010, Vol. 71, No. 2
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.2.1008-1010.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Migration through the Extracellular Matrix by the Parasitic Protozoan Leishmania Is Enhanced by Surface Metalloprotease gp63

Bradford S. McGwire,1,2* Kwang-Poo Chang,3 and David M. Engman1*

Departments of Pathology and Microbiology-Immunology, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611,1 Section of Infectious Diseases, College of Medicine, University of Illinois, Chicago, Illinois 60612,2 Department of Microbiology and Immunology, University of the Health Sciences, North Chicago, Illinois 600643

Received 5 August 2002/ Returned for modification 17 September 2002/ Accepted 12 November 2002

Leishmania species engineered to express high levels of the surface metalloprotease gp63 have enhanced capacity of migration through extracellular matrix in vitro. This correlates with gp63 degradation of extracellular matrix components, such as collagen type IV and fibronectin, and suggests an important role for gp63 in the pathogenesis of leishmaniasis.

* Corresponding author. Mailing address: Northwestern University, Department of Pathology, 303 E. Chicago Ave., Ward 6-140, Chicago, Illinois 60611. Phone: (312) 503-1267. Fax: (312) 503-1265. E-mail for Bradford S. McGwire: b-mcgwire{at}northwestern.edu. E-mail for David M. Engman: d-engman{at}northwestern.edu.

Editor: J. M. Mansfield

Infection and Immunity, February 2003, p. 1008-1010, Vol. 71, No. 2
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.2.1008-1010.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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