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Infection and Immunity, March 2003, p. 1587-1589, Vol. 71, No. 3
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.3.1587-1589.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Interleukin-12 Regulates Chemokine Gene Expression during the Early Immune Response to Leishmania major

Colby Zaph and Phillip Scott*

Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104

Received 16 August 2002/ Returned for modification 12 November 2002/ Accepted 13 December 2002

Following infection with Leishmania major, the chemokines XCL1, CXCL10, and CCL2 were preferentially expressed in draining lymph nodes of resistant mice. Neutralization of interleukin 12 (IL-12) or gamma interferon in resistant mice resulted in decreased chemokine expression, while administration of IL-12 to susceptible mice resulted in an increase in the level of chemokine gene expression.

* Corresponding author. Mailing address: Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce St., Philadelphia, PA 19104. Phone: (215) 898-1602. Fax: (215) 573-7023. E-mail: pscott{at}mail.vet.upenn.edu.

Editor: J. M. Mansfield

Infection and Immunity, March 2003, p. 1587-1589, Vol. 71, No. 3
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.3.1587-1589.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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