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Infection and Immunity, March 2003, p. 1596-1598, Vol. 71, No. 3
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.3.1596-1598.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Effect of Vaccination with Refined Components of the Organism on Infection of Mice with Mycobacterium leprae

Maeya Ngamying,1 Pathom Sawanpanyalert,1 Raywadee Butraporn,1 Junjira Nikasri,1 Sang-Nae Cho,2 Louis Levy,1 and Patrick J. Brennan3*

National Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi 11000, Thailand,1 Department of Microbiology, Yonsei University, Seoul, Republic of Korea,2 Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado3

Received 6 September 2002/ Returned for modification 1 November 2002/ Accepted 25 November 2002

Only native products of Mycobacterium leprae, whether cell wall, cytosol, or membrane derived, can confer protective immunity against challenge in the mouse footpad. Previously, recombinant proteins were shown to be ineffective. The cell wall skeleton—the mycolyl-arabinogalactan-peptidoglycan complex—devoid of proteins is not protective.

* Corresponding author. Mailing address: Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523-1677. Phone: (970) 491-6700. Fax: (970) 491-1815. E-mail: Patrick.Brennan{at}ColoState.edu.

Editor: W. A. Petri, Jr.

Infection and Immunity, March 2003, p. 1596-1598, Vol. 71, No. 3
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.3.1596-1598.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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