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Infection and Immunity, March 2003, p. 1604-1607, Vol. 71, No. 3
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.3.1604-1607.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Bacterial [Cu,Zn]-Cofactored Superoxide Dismutase Protects Opsonized, Encapsulated Neisseria meningitidis from Phagocytosis by Human Monocytes/Macrophages

Kate L. R. Dunn,{dagger} Jayne L. Farrant, Paul R. Langford, and J. Simon Kroll*

Molecular Infectious Diseases Group, Department of Paediatrics, Faculty of Medicine, Imperial College, St. Mary's Hospital Campus, London W2 1PG, United Kingdom

Received 15 July 2002/ Returned for modification 11 October 2002/ Accepted 25 November 2002

Superoxide dismutase cofactored by copper and zinc ([Cu,Zn]-SOD) contributes to the protection of opsonized serogroup B Neisseria meningitidis against phagocytosis by human monocytes/macrophages, with sodC mutant organisms being endocytosed in significantly higher numbers than are wild-type organisms. The influence of [Cu,Zn]-SOD was found to be exerted at the stage of phagocytosis, rather than at earlier (modulating surface association) or later (intracellular killing) stages.

* Corresponding author. Mailing address: Department of Paediatrics, Molecular Infectious Diseases Group, Imperial College, St. Mary's Hospital Campus, Norfolk Pl., London W2 1PG, United Kingdom. Phone: (44) (0)20 7886 6220. Fax: (44) (0)20 7886 6284. E-mail: s.kroll{at}imperial.ac.uk.

Editor: A. D. O'Brien

{dagger} Present address: Hammersmith Medicines Research Ltd., Central Middlesex Hospital, Park Royal, London NW10 7NS, United Kingdom.

Infection and Immunity, March 2003, p. 1604-1607, Vol. 71, No. 3
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.3.1604-1607.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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