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Infection and Immunity, April 2003, p. 1828-1832, Vol. 71, No. 4
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.4.1828-1832.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Characterization of Cryptosporidium meleagridis of Human Origin Passaged through Different Host Species

Donna E. Akiyoshi, Julia Dilo, Christine Pearson, Susan Chapman, James Tumwine, and Saul Tzipori*

Department of Biomedical Sciences, Tufts University School of Veterinary Medicine, North Grafton, Massachusetts 01536

Received 22 October 2002/ Returned for modification 10 December 2002/ Accepted 17 December 2002

Cryptosporidium meleagridis, a protozoon first observed in turkeys, has been linked by several investigators to cryptosporidiosis in humans. C. meleagridis is the only known Cryptosporidium species that infects both avian and mammalian species. We describe the successful propagation of C. meleagridis (isolate TU1867), originally purified from a patient with diarrhea, in laboratory animals including chickens, mice, piglets, and calves. TU1867 was readily transmitted from one animal host to another, maintaining genetic homogeneity and stability. The rate of infectivity and virulence of TU1867 for the mammalian species were similar to those of Cryptosporidium parvum. Laboratory propagation of genetically and phenotypically stable and well-characterized reference isolates, representing various Cryptosporidium species, particularly those infectious to humans, will improve considerably the spectrum and quality of laboratory and field investigations on this medically important protozoa.

* Corresponding author. Mailing address: Tufts University School of Veterinary Medicine, 200 Westboro Rd., Building 20, North Grafton, MA 01536. Phone: (508) 839-7955. Fax: (508) 839-7977. E-mail: saul.tzipori{at}tufts.edu.

Editor: W. A. Petri, Jr.

Infection and Immunity, April 2003, p. 1828-1832, Vol. 71, No. 4
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.4.1828-1832.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Brescia, C. C., Griffin, S. M., Ware, M. W., Varughese, E. A., Egorov, A. I., Villegas, E. N. (2009). Cryptosporidium Propidium Monoazide-PCR, a Molecular Biology-Based Technique for Genotyping of Viable Cryptosporidium Oocysts. Appl. Environ. Microbiol. 75: 6856-6863 [Abstract] [Full Text]  
  • CHAPPELL, C. L., OKHUYSEN, P. C., LANGER-CURRY, R., WIDMER, G., AKIYOSHI, D. E., TANRIVERDI, S., TZIPORI, S. (2006). CRYPTOSPORIDIUM HOMINIS: EXPERIMENTAL CHALLENGE OF HEALTHY ADULTS. Am J Trop Med Hyg 75: 851-857 [Abstract] [Full Text]  
  • Xiao, L., Fayer, R., Ryan, U., Upton, S. J. (2004). Cryptosporidium Taxonomy: Recent Advances and Implications for Public Health. Clin. Microbiol. Rev. 17: 72-97 [Abstract] [Full Text]  


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