This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bourreau, E.
Right arrow Articles by Pascal, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bourreau, E.
Right arrow Articles by Pascal, L.

 Previous Article  |  Next Article 

Infection and Immunity, April 2003, p. 2244-2246, Vol. 71, No. 4
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.4.2244-2246.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Th2 Responses Predominate during the Early Phases of Infection in Patients with Localized Cutaneous Leishmaniasis and Precede the Development of Th1 Responses

Eliane Bourreau,1 Jacques Gardon,2 Roger Pradinaud,3 Hervé Pascalis,1,4 Ghislaine Prévot-Linguet,1,4 Amina Kariminia,1 and Launois Pascal1*

Immunologie des Leishmanioses,1 Service d'Epidémiologie, Institut Pasteur,2 Institut Guyanais de Dermatologie Tropicale, E.A. 2188, Centre Hospitalier Andrée Rosemon,3 Institut d'Enseignement Supérieur de la Guyane, Université Antilles-Guyane, Cayenne, French Guiana4

Received 1 October 2002/ Returned for modification 19 November 2002/ Accepted 9 January 2003

Intralesional Th2 responses preceded the development of Th1 responses in localized cutaneous leishmaniasis due to Leishmania guyanensis. Although the number of parasites increased in Th2 lesions, no correlation was found between the levels of cytokine expression and the number of parasites. In contrast, the decreased number of parasites in Th1 lesions is negatively correlated to gamma interferon expression.

* Corresponding author. Mailing address: Immunologie des Leishmanioses, Institut Pasteur de la Guyane, BP 6010, 97306 Cayenne Cedex, French Guiana. Phone: 594 594 29 26 13. Fax: 594 594 31 80 83. E-mail: plaunois{at}pasteur-cayenne.fr.

Editor: J. M. Mansfield

Infection and Immunity, April 2003, p. 2244-2246, Vol. 71, No. 4
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.4.2244-2246.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Bourreau, E., Ronet, C., Darcissac, E., Lise, M. C., Sainte Marie, D., Clity, E., Tacchini-Cottier, F., Couppie, P., Launois, P. (2009). Intralesional Regulatory T-Cell Suppressive Function during Human Acute and Chronic Cutaneous Leishmaniasis Due to Leishmania guyanensis. Infect. Immun. 77: 1465-1474 [Abstract] [Full Text]  
  • Matta, N. E., Nogueira, R. S., Franco, A. M. R., de Souza e Souza, I., Mattos, M. S., Oliveira-Neto, M. P., Coutinho, S. G., Leon, L. L., Da-Cruz, A. M. (2009). Leishmania (Viannia) guyanensis Induces Low Immunologic Responsiveness in Leishmaniasis Patients from an Endemic Area of the Brazilian Amazon Highland. Am J Trop Med Hyg 80: 339-344 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»