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Infection and Immunity, April 2003, p. 2288-2291, Vol. 71, No. 4
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.4.2288-2291.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Bidirectional Concentration-Dependent Effects of Tumor Necrosis Factor Alpha in Shigella dysenteriae-Related Seizures

Yael Yuhas,1,2* Abraham Weizman,1,2 and Shai Ashkenazi1,2,3

Felsenstein Medical Research Center,1 Schneider Children's Medical Center of Israel, Beilinson Campus, Petah Tikva,3 Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel2

Received 26 August 2002/ Accepted 3 January 2003

We have previously demonstrated that pretreatment of mice with Shigella dysenteriae sonicate enhanced their susceptibility to pentylenetetrazole-induced seizures and that tumor necrosis factor alpha (TNF-{alpha}) was proconvulsive in this respect. The present study shows that TNF-{alpha}, at high concentrations, may also exert a suppressive effect on Shigella-mediated seizures. This implies that high levels of TNF-{alpha} may play a protective role in neurologic complications of S. dysenteriae infection.

* Corresponding author. Mailing address: Unit of Infectious Diseases, Schneider Children's Medical Center of Israel, P.O. Box 8145, Petah Tikva 49181, Israel. Phone: 972-3-9253680/3792. Fax: 972-3-9253056. E-mail: ashai{at}post.tau.ac.il.

Editor: J. D. Clements

Infection and Immunity, April 2003, p. 2288-2291, Vol. 71, No. 4
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.4.2288-2291.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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