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Infection and Immunity, April 2003, p. 2292-2295, Vol. 71, No. 4
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.4.2292-2295.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

The Fibronectin-Binding Proteins of Staphylococcus aureus May Promote Mammary Gland Colonization in a Lactating Mouse Model of Mastitis

Eric Brouillette, Brian G. Talbot, and François Malouin*

Centre d'Étude et de Valorisation de la Diversité Microbienne (CEVDM), Département de Biologie, Faculté des Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada J1K 2R1

Received 23 October 2002/ Returned for modification 28 November 2002/ Accepted 13 January 2003

The fibronectin-binding proteins (FnBPs) of Staphylococcus aureus are believed to be implicated in the pathogen's adherence to and colonization of bovine mammary glands, thus leading to infectious mastitis. In vitro studies have shown that FnBPs help the adhesion of the pathogen to bovine mammary epithelial cells. However, the importance of FnBPs for the infection of mammary glands has never been directly established in vivo. In this study with a mouse model of mastitis, the presence of FnBPs on the surface of S. aureus increased the capacity of the bacterium to colonize mammary glands under suckling pressure compared to that of a mutant lacking FnBPs.

* Corresponding author. Mailing address: Département de biologie, Faculté des sciences, Université de Sherbrooke, 2500 Boul. Université, Sherbrooke, QC, Canada J1K 2R1. Phone: (819) 821-8000, ext. 1202. Fax: (819) 821-8049. E-mail: francois.malouin{at}usherbrooke.ca.

Editor: B. B. Finlay

Infection and Immunity, April 2003, p. 2292-2295, Vol. 71, No. 4
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.4.2292-2295.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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