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Infection and Immunity, May 2003, p. 2924-2926, Vol. 71, No. 5
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.5.2924-2926.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Th1 Cell Development Induced by Cysteine Proteinases A and B in Localized Cutaneous Leishmaniasis Due to Leishmania guyanensis

Hervé Pascalis,1,2 Anne Lavergne,3 Eliane Bourreau,1 Ghislaine Prévot-Linguet,1,2 Amina Kariminia,1 Roger Pradinaud,4 Sima Rafati,5 and Pascal Launois1*

Immunologie des Leishmanioses,1 Parasitologie Moléculaire, Institut Pasteur de le Guyane Française,3 Institut d'Etudes Supérieures de la Guyane, Université Antilles-Guyane,2 Institut Guyanais de Dermatologie Tropicale, E.A. 2188, Centre Hospitalier Andrée Rosemon, Cayenne, French Guiana,4 Immunology Department, Institute Pasteur of Iran, Teheran, Iran5

Received 29 October 2002/ Returned for modification 21 December 2002/ Accepted 17 January 2003

The cysteine proteinases CPA and CPB from Leishmania major induced Th1 responses in patients with leishmaniasis due to Leishmania guyanensis. Furthermore, cysteine proteinases induced neither interleukin 4 (IL-4) nor IL-13 and low levels of IL-10 in controls and patients. The results suggest that CPs would be quite good candidates for a vaccine against different Leishmania species.

* Corresponding author. Mailing address: Immunologie des Leishmanioses, Institut Pasteur de la Guyane, BP 6010, 97306 Cayenne Cedex, French Guiana. Phone: 0594 594 29 26 13. Fax: 0594 594 31 80 83. E-mail: plaunois{at}pasteur-cayenne.fr.

Editor: W. A. Petri, Jr.

Infection and Immunity, May 2003, p. 2924-2926, Vol. 71, No. 5
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.5.2924-2926.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.





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