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Infection and Immunity, May 2003, p. 2960-2965, Vol. 71, No. 5
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.5.2960-2965.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Binding of Intimin from Enteropathogenic Escherichia coli to Lymphocytes and Its Functional Consequences

Nathalie S. Gonçalves,1 Christine Hale,2 Gordon Dougan,2 Gad Frankel,2 and Thomas T. MacDonald1*

School of Medicine, University of Southampton, Southampton General Hospital, Southampton SO16 6YD,1 Centre for Molecular Microbiology and Infection, Department of Biochemistry, Imperial College of Science, Technology and Medicine, London SW7 2AZ, United Kingdom2

Received 19 August 2002/ Returned for modification 1 November 2002/ Accepted 11 February 2003

Intimin-conjugated fluorescent beads bind to spleen CD4 T cells and Peyer's patch, mesenteric lymph node, and cecal follicle lymphocytes, with less binding to lamina propria T cells and intraepithelial lymphocytes. Intimin costimulates proliferation of spleen CD4 T cells and cells from organized lymphoid tissues but does not costimulate cells from the lamina propria of normal or inflamed colon.

* Corresponding author. Mailing address: Division of Infection, Inflammation and Repair, School of Medicine, University of Southampton, Mail Point 813, Level E, South Block, Southampton General Hospital, Tremona Rd., Southampton SO16 6YD, United Kingdom. Phone: 02380 794754. Fax: 02380 7965025. E-mail: t.t.macdonald{at}soton.ac.uk.

Editor: A. D. O'Brien

Infection and Immunity, May 2003, p. 2960-2965, Vol. 71, No. 5
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.5.2960-2965.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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