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Infection and Immunity, June 2003, p. 3619-3622, Vol. 71, No. 6
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.6.3619-3622.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

The FimH A27V Mutation Is Pathoadaptive for Urovirulence in Escherichia coli B2 Phylogenetic Group Isolates

Florence Hommais,1 Stéphanie Gouriou,2 Christine Amorin,1 Hung Bui,3 Mohamed Chérif Rahimy,4 Bertrand Picard,2 and Erick Denamur1*

INSERM U458, Hôpital Robert Debré,1 Centre d'Etude du Polymorphisme Humain, Hôpital Saint Louis, Paris,3 Laboratoire de Microbiologie, Hôpital Morvan, Brest, France,2 Faculté des Sciences de la Santé, Cotonou, République du Bénin4

Received 21 October 2002/ Returned for modification 23 December 2002/ Accepted 13 March 2003

Correlations between FimH mutations and virulence were established by studying a collection of human commensal and extraintestinal pathogenic Escherichia coli natural isolates. Pathoadaptive (A27V and, to a lesser extent, A119V) and "commensal-adaptive" (A202V) mutations were evidenced in B2 phylogenetic group strains. fimH phylogenetic analysis indicates that these pathoadaptive mutations occurred several times.

* Corresponding author. Mailing address: INSERM E03 39, IFR 02, Faculté de Médecine Xavier Bichat, 16 rue Henri Huchard, 75018 Paris, France. Phone: 33 (1) 44 85 61 56. Fax: 33 (1) 44 85 61 49. E-mail: denamur{at}bichat.inserm.fr.

Editor: V. J. DiRita

Infection and Immunity, June 2003, p. 3619-3622, Vol. 71, No. 6
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.6.3619-3622.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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