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Infection and Immunity, June 2003, p. 3639-3644, Vol. 71, No. 6
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.6.3639-3644.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Complete Sequence of the cap Locus of Haemophilus influenzae Serotype b and Nonencapsulated b Capsule-Negative Variants

Sarah W. Satola, Patricia L. Schirmer, and Monica M. Farley*

Atlanta Veterans Affairs Medical Center and Department of Medicine, Emory University School of Medicine, Decatur, Georgia 30033

Received 3 December 2002/ Returned for modification 6 February 2003/ Accepted 13 March 2003

The complete capsule (cap) loci from three Haemophilus influenzae strains, one serotype b (Hib) and two nonencapsulated b capsule-negative variants, were sequenced. Two new open reading frames, hcsA and hcsB, were identified in region III and thought to be involved in postpolymerization modification of the capsule. The location of the cap locus in the Haemophilus influenzae chromosome was identified within section 97 of the Rd genome (chromosomal coordinates 1074542 to 1086327) and found to be the same for the Hib and two Hib- strains as well as some other encapsulated division I H. influenzae strains.

* Corresponding author. Mailing address: Atlanta VA Medical Center, Medical Research Service 151, 1670 Clairmont Rd., Decatur, GA 30033. Phone: (404) 728-7688. Fax: (404) 329-2210. E-mail: mfarley{at}emory.edu.

Editor: J. N. Weiser

Infection and Immunity, June 2003, p. 3639-3644, Vol. 71, No. 6
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.6.3639-3644.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Satola, S. W., Collins, J. T., Napier, R., Farley, M. M. (2007). Capsule Gene Analysis of Invasive Haemophilus influenzae: Accuracy of Serotyping and Prevalence of IS1016 among Nontypeable Isolates. J. Clin. Microbiol. 45: 3230-3238 [Abstract] [Full Text]  
  • Sukupolvi-Petty, S., Grass, S., StGeme, J. W. III (2006). The Haemophilus influenzae Type b hcsA and hcsB Gene Products Facilitate Transport of Capsular Polysaccharide across the Outer Membrane and Are Essential for Virulence. J. Bacteriol. 188: 3870-3877 [Abstract] [Full Text]  
  • Tzeng, Y.-L., Datta, A. K., Strole, C. A., Lobritz, M. A., Carlson, R. W., Stephens, D. S. (2005). Translocation and Surface Expression of Lipidated Serogroup B Capsular Polysaccharide in Neisseria meningitidis. Infect. Immun. 73: 1491-1505 [Abstract] [Full Text]  
  • Satola, S. W., Schirmer, P. L., Farley, M. M. (2003). Genetic Analysis of the Capsule Locus of Haemophilus influenzae Serotype f. Infect. Immun. 71: 7202-7207 [Abstract] [Full Text]  


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