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Infection and Immunity, July 2003, p. 4137-4143, Vol. 71, No. 7
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.7.4137-4143.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Bordetella bronchiseptica Persists in the Nasal Cavities of Mice and Triggers Early Delivery of Dendritic Cells in the Lymph Nodes Draining the Lower and Upper Respiratory Tract

Pascale Gueirard,1* Patrick Ave,2 Anne-Marie Balazuc,3 Sabine Thiberge,1 Michel Huerre,2 Genevieve Milon,4 and Nicole Guiso1

Unité des Bordetella,1 Unité de Recherche et d'Expertise Histotechnologie et Pathologie,2 Laboratoire de Cytométrie Analytique et Préparative,3 Unité d'Immunophysiologie et Parasitisme Intracellulaire, Institut Pasteur, Paris, France4

Received 26 December 2002/ Returned for modification 14 February 2003/ Accepted 27 March 2003

Early after the intranasal instillation of Bordetella bronchiseptica into mice, not only are mature dendritic leukocytes recovered from lung parenchyma and bronchoalveolar lavage fluid but their numbers are also increased in the mediastinal lymph nodes and the nasal mucosa-associated lymphoid tissue. Later during the infectious process, the bacteria persist mainly in the nasal cavity.

* Corresponding author. Mailing address: Unité des Neisseria, Institut Pasteur, 25 rue du Dr. Roux, 75724 Paris cedex 15, France. Phone: 33 1 45 68 83 33. Fax: 33 1 40 61 35 33. E-mail: pgueirar{at}pasteur.fr.

Editor: J. N. Weiser

Infection and Immunity, July 2003, p. 4137-4143, Vol. 71, No. 7
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.7.4137-4143.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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