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Infection and Immunity, July 2003, p. 4167-4170, Vol. 71, No. 7
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.7.4167-4170.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

The {sigma}B Regulon Influences Internalization of Staphylococcus aureus by Osteoblasts

Sean P. Nair,1* Markus Bischoff,2 Maria M. Senn,2 and Brigitte Berger-Bächi2

Cellular Microbiology Research Group, Eastman Dental Institute for Oral Health Care Sciences, University College London, London WC1X 8LD, United Kingdom,1 Institute for Medical Microbiology, University of Zürich, CH-8028 Zürich, Switzerland2

Received 29 July 2002/ Returned for modification 18 December 2002/ Accepted 21 April 2003

Individual strains of Staphylococcus aureus have different capacities to become internalized by osteoblasts. Here we report that the levels of {sigma}B expressed by S. aureus correlate with the capacity of this bacterium to be internalized by osteoblasts. However, {sigma}B is not essential for internalization and does not necessarily account for the differences in the capacities of strains to be internalized.

* Corresponding author. Mailing address: Cellular Microbiology Research Group, Eastman Dental Institute, University College London, 256 Gray's Inn Rd., London WC1X 8LD, United Kingdom. Phone: 44(0)20 79151118. Fax: 44(0)20 79151127. E-mail: snair{at}eastman.ucl.ac.uk.

Editor: V. J. DiRita

Infection and Immunity, July 2003, p. 4167-4170, Vol. 71, No. 7
0019-9567/03/$08.00+0     DOI: 10.1128/IAI.71.7.4167-4170.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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